Exploration of all the cells in a low grade glioma using single cell deep sequencing techniques
Written By: Dr. Nick Foreman, Lead Researcher & Neuro-oncologist, Children's Hospital Colorado
We can now use new sequencing techniques to look at the entire DNA of a single cell. By looking at this for thousands of cells in a tumor we can obtain an in-depth look at not only what each cell in a tumor is but what each cell is programmed to do.
This technique has revealed not only that 40% of a Low Grade Glioma is made up of immune cells, but also that the immune population is complex with both pro-tumor and anti-tumor populations. Understanding this complex situation is vital in the development of immune therapies.
This work is supported directly with OCF funding and 24 children's tumors have been completely analyzed. The initial data is being used to apply for expanded funding from the National Cancer Institute to supplement that of OCF.
This technique has revealed not only that 40% of a Low Grade Glioma is made up of immune cells, but also that the immune population is complex with both pro-tumor and anti-tumor populations. Understanding this complex situation is vital in the development of immune therapies.
This work is supported directly with OCF funding and 24 children's tumors have been completely analyzed. The initial data is being used to apply for expanded funding from the National Cancer Institute to supplement that of OCF.
